SDI11773.1 protein (Sinosporangium album) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SDI11773.1

Cytochrome P450. (402 aa)

Predicted Functional Partners:

SDH95965.1

0.998

SDI47343.1

0.992

SDH95939.1

0.988

SDH96069.1

0.982

SDH10822.1

0.944

SDI07972.1

0.944

SDI47357.1

0.915

SDH96036.1

0.914

SDG75593.1

0.878

SDG15943.1

0.828

Your Current Organism:

Sinosporangium album

NCBI taxonomy Id: 504805
Other names: DSM 45181, KCTC 19655, S. album, Sinosporangium album Zang et al. 2011, Streptosporangineae bacterium 6014, strain 6014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDG15943.1	SDG75593.1	SAMN05421505_102102	SAMN05421505_107195	Phosphopantetheine attachment site.	Acyl transferase domain-containing protein.	0.987
SDG15943.1	SDH10822.1	SAMN05421505_102102	SAMN05421505_111153	Phosphopantetheine attachment site.	Non-ribosomal peptide synthetase component F.	0.996
SDG15943.1	SDH95939.1	SAMN05421505_102102	SAMN05421505_12825	Phosphopantetheine attachment site.	Amino acid adenylation domain-containing protein/thioester reductase domain-containing protein.	0.986
SDG15943.1	SDH95965.1	SAMN05421505_102102	SAMN05421505_12826	Phosphopantetheine attachment site.	Nonribosomal peptide synthetase DhbF.	0.999
SDG15943.1	SDH96036.1	SAMN05421505_102102	SAMN05421505_12828	Phosphopantetheine attachment site.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.999
SDG15943.1	SDH96069.1	SAMN05421505_102102	SAMN05421505_12829	Phosphopantetheine attachment site.	Amino acid adenylation domain-containing protein.	0.999
SDG15943.1	SDI07972.1	SAMN05421505_102102	SAMN05421505_13315	Phosphopantetheine attachment site.	Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein.	0.967
SDG15943.1	SDI11773.1	SAMN05421505_102102	SAMN05421505_13459	Phosphopantetheine attachment site.	Cytochrome P450.	0.828
SDG15943.1	SDI47343.1	SAMN05421505_102102	SAMN05421505_1562	Phosphopantetheine attachment site.	Acyl transferase domain-containing protein.	0.998
SDG15943.1	SDI47357.1	SAMN05421505_102102	SAMN05421505_1563	Phosphopantetheine attachment site.	Acyl transferase domain-containing protein.	0.998
SDG75593.1	SDG15943.1	SAMN05421505_107195	SAMN05421505_102102	Acyl transferase domain-containing protein.	Phosphopantetheine attachment site.	0.987
SDG75593.1	SDH10822.1	SAMN05421505_107195	SAMN05421505_111153	Acyl transferase domain-containing protein.	Non-ribosomal peptide synthetase component F.	0.998
SDG75593.1	SDH95939.1	SAMN05421505_107195	SAMN05421505_12825	Acyl transferase domain-containing protein.	Amino acid adenylation domain-containing protein/thioester reductase domain-containing protein.	0.999
SDG75593.1	SDH95965.1	SAMN05421505_107195	SAMN05421505_12826	Acyl transferase domain-containing protein.	Nonribosomal peptide synthetase DhbF.	0.999
SDG75593.1	SDH96036.1	SAMN05421505_107195	SAMN05421505_12828	Acyl transferase domain-containing protein.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.999
SDG75593.1	SDH96069.1	SAMN05421505_107195	SAMN05421505_12829	Acyl transferase domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SDG75593.1	SDI07972.1	SAMN05421505_107195	SAMN05421505_13315	Acyl transferase domain-containing protein.	Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein.	0.998
SDG75593.1	SDI11773.1	SAMN05421505_107195	SAMN05421505_13459	Acyl transferase domain-containing protein.	Cytochrome P450.	0.878
SDG75593.1	SDI47343.1	SAMN05421505_107195	SAMN05421505_1562	Acyl transferase domain-containing protein.	Acyl transferase domain-containing protein.	0.992
SDG75593.1	SDI47357.1	SAMN05421505_107195	SAMN05421505_1563	Acyl transferase domain-containing protein.	Acyl transferase domain-containing protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.706

expected number of edges:

12

PPI enrichment p-value:

0.0413

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006220

Pyrimidine nucleotide metabolic process

4 of 21

2.0

2.1

5.06e-05

GO:0009218

Pyrimidine ribonucleotide metabolic process

3 of 12

2.12

1.84

0.00026

GO:0009123

Nucleoside monophosphate metabolic process

4 of 46

1.66

1.64

0.00019

GO:0009117

Nucleotide metabolic process

6 of 121

1.42

1.56

5.06e-05

GO:0009165

Nucleotide biosynthetic process

5 of 89

1.47

1.54

0.00011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019205

Nucleobase-containing compound kinase activity

4 of 9

2.37

2.83

3.49e-06

GO:0019206

Nucleoside kinase activity

2 of 3

2.55

1.17

0.0073

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

2 of 11

1.98

0.99

0.0128

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 421

0.88

0.62

0.0073

GO:0032555

Purine ribonucleotide binding

6 of 422

0.88

0.62

0.0073

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 1717

0.49

0.37

0.0052

GO:0005737

Cytoplasm

9 of 1574

0.48

0.34

0.0156

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1451

Mixed, incl. Coenzyme A metabolic process, and Pantothenate biosynthesis

4 of 15

2.15

2.47

1.14e-05

CL:1289

Mixed, incl. Nucleoside monophosphate metabolic process, and Folate biosynthesis

7 of 96

1.59

2.39

1.79e-07

CL:1469

Chromosome segregation, and rRNA pseudouridine synthesis

3 of 6

2.42

2.05

0.00014

CL:1291

Ribonucleoside monophosphate metabolic process, and Pyrimidine metabolism

3 of 58

1.44

0.65

0.0444

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

6 of 68

1.67

2.54

2.00e-07

map00230

Purine metabolism

4 of 113

1.27

0.98

0.0030

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

6 of 482

0.82

0.47

0.0354

GOCC:0005737

Cytoplasm

8 of 1127

0.57

0.36

0.0354

GOCC:0005622

Intracellular

9 of 1664

0.46

0.3

0.0436

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0547

Nucleotide-binding

6 of 301

1.02

0.83

0.0016

KW-0963

Cytoplasm

5 of 224

1.07

0.81

0.0036

KW-0418

Kinase

4 of 171

1.09

0.68

0.0155

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