node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KGQ69572.1 | KGQ71248.1 | OA57_10795 | OA57_03210 | Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.544 |
KGQ69572.1 | cobB | OA57_10795 | OA57_04740 | Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 0.728 |
KGQ70475.1 | cobB | OA57_06435 | OA57_04740 | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 0.971 |
KGQ70475.1 | deoD | OA57_06435 | OA57_01120 | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.712 |
KGQ70475.1 | nadE | OA57_06435 | OA57_04900 | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.802 |
KGQ70475.1 | nudC | OA57_06435 | OA57_10140 | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | NADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.671 |
KGQ70475.1 | ppnK | OA57_06435 | OA57_02945 | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.801 |
KGQ70675.1 | cobB | OA57_04735 | OA57_04740 | 23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 0.768 |
KGQ71248.1 | KGQ69572.1 | OA57_03210 | OA57_10795 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.544 |
KGQ71248.1 | cobB | OA57_03210 | OA57_04740 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 0.574 |
KGQ71361.1 | cobB | OA57_00775 | OA57_04740 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 0.649 |
cobB | KGQ69572.1 | OA57_04740 | OA57_10795 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.728 |
cobB | KGQ70475.1 | OA57_04740 | OA57_06435 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.971 |
cobB | KGQ70675.1 | OA57_04740 | OA57_04735 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | 23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.768 |
cobB | KGQ71248.1 | OA57_04740 | OA57_03210 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.574 |
cobB | KGQ71361.1 | OA57_04740 | OA57_00775 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.649 |
cobB | deoD | OA57_04740 | OA57_01120 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.635 |
cobB | nadE | OA57_04740 | OA57_04900 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.630 |
cobB | nudC | OA57_04740 | OA57_10140 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | NADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.632 |
cobB | pntA | OA57_04740 | OA57_09530 | NAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.606 |