Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EDM43399.1ARA1; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (280 aa)    
Predicted Functional Partners:
EDM44487.1
Iron-containing alcohol dehydrogenase; COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family.
  
 
 0.825
EDM45368.1
Probable nucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase.
     
 0.794
EDM45627.1
COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases).
 
0.790
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.788
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.788
EDM43144.1
COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
  0.788
EDM43398.1
Hypothetical protein.
       0.732
EDM45709.1
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; COG1171 Threonine dehydratase.
   
 
  0.676
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
  0.676
EDM43400.1
Hypothetical protein.
       0.651
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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