Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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EDM43534.1Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (426 aa)    
Predicted Functional Partners:
EDM45480.1
COG3508 Homogentisate 1,2-dioxygenase.
 
 0.919
EDM45153.1
COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins.
 
  
 0.836
EDM43089.1
Probable oxidoreductase; COG0277 FAD/FMN-containing dehydrogenases.
    
  0.827
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
  0.810
sdhA
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
  
 
  0.806
EDM44339.1
COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
  0.793
EDM44341.1
COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit.
    
  0.791
EDM43947.1
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase, fumarylacetoacetate hydrolase family protein; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway).
     
  0.788
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
    0.548
EDM43535.1
Hypothetical protein.
    
  0.538
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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