Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EDM44298.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)    
Predicted Functional Partners:
EDM44267.1
COG0281 Malic enzyme.
   
 0.955
EDM44435.1
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.927
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
    
 0.903
EDM43140.1
COG1984 Allophanate hydrolase subunit 2.
    
 0.901
EDM45182.1
propionyl-CoA carboxylase beta chain; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).
 
 0.890
EDM44743.1
COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.
    
 0.889
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
   
 0.887
EDM44279.1
Molybdopterin oxidoreductase, iron-sulfur binding subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
     
  0.875
EDM43846.1
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.868
EDM43089.1
Probable oxidoreductase; COG0277 FAD/FMN-containing dehydrogenases.
    
 0.855
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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