STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EDM44397.1Glyoxalase family protein; COG0346 Lactoylglutathione lyase and related lyases. (127 aa)    
Predicted Functional Partners:
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
    
 0.887
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
   
  0.789
EDM43467.1
Metallo-beta-lactamase superfamily protein; COG0491 Zn-dependent hydrolases, including glyoxylases.
   
 0.788
EDM45006.1
Rhodanese-like protein; COG0491 Zn-dependent hydrolases, including glyoxylases.
   
 0.788
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.786
EDM43144.1
COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
  0.785
EDM45709.1
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; COG1171 Threonine dehydratase.
     
  0.661
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
  0.661
EDM44743.1
COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.
    
 0.635
EDM42911.1
Ferredoxin 2 with 4Fe-4S binding domain; COG1145 Ferredoxin.
   
 
  0.568
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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