Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EDM45438.1Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
EDM45437.1
DNA methylase, putative; COG2852 Uncharacterized protein conserved in bacteria.
 0.997
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.997
hemE
Uroporphyrinogen-III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 0.996
EDM45429.1
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemL
HemL; COG0001 Glutamate-1-semialdehyde aminotransferase.
  
 0.957
EDM43659.1
COG1587 Uroporphyrinogen-III synthase.
  
 0.947
EDM45432.1
COG0408 Coproporphyrinogen III oxidase.
  
 
 0.703
EDM45440.1
Transcriptional regulator; COG2207 AraC-type DNA-binding domain-containing proteins.
       0.547
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.527
EDM45435.1
Hypothetical protein.
       0.483
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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