STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EDM43787.1Putative acetyl-CoA hydrolase/transferase; COG0427 Acetyl-CoA hydrolase. (500 aa)    
Predicted Functional Partners:
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
  
 
 0.985
sucC
succinate--CoA ligase, ADP-forming (succinyl-CoA synthetase, beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.935
EDM44743.1
COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.
  
 
 0.935
EDM43846.1
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 0.933
EDM43597.1
Bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; COG1012 NAD-dependent aldehyde dehydrogenases.
  
 
 0.923
EDM44560.1
succinate--CoA ligase, ADP-forming (succinyl-CoA synthetase, alpha subunit); COG0074 Succinyl-CoA synthetase, alpha subunit.
   
 0.890
EDM44504.1
COG1454 Alcohol dehydrogenase, class IV.
  
 
 0.819
EDM44220.1
Dihydrolipoyllysine-residue acetyltransferase (dihydrolipoamide S-acetyltransferase); COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes.
   
  0.814
EDM45600.1
Dihydrolipoyllysine-residue succinyltransferase, component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
   
  0.814
EDM44339.1
COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
   
 
 0.813
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.