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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDM43984.1Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. (193 aa)    
Predicted Functional Partners:
EDM44474.1
Hypothetical protein; COG1388 FOG: LysM repeat.
   
 
 0.725
EDM44590.1
DNA topoisomerase IV, subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit.
   
 
 0.680
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.679
EDM44435.1
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.625
EDM43983.1
Hypothetical protein.
       0.615
EDM43985.1
Hypothetical protein.
       0.491
EDM45577.1
COG0209 Ribonucleotide reductase, alpha subunit.
    
  0.468
mazG
Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase.
    
  0.457
EDM44773.1
GTP diphosphokinase (guanosine 3',5'-polyphosphate synthase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
  0.453
EDM44230.1
Hypothetical protein; COG0535 Predicted Fe-S oxidoreductases.
   
 
  0.443
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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