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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Score
EDM44029.1COG2008 Threonine aldolase. (342 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.938
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.884
ychF
Translation-associated GTPase; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
      0.867
EDM45746.1
COG0498 Threonine synthase.
    
 0.851
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
     
 0.798
EDM44035.1
2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.
     
 0.798
EDM44360.1
Short-chain dehydrogenase/reductase SDR; COG4221 Short-chain alcohol dehydrogenase of unknown specificity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
  0.794
EDM44042.1
COG0665 Glycine/D-amino acid oxidases (deaminating).
     
  0.788
EDM45061.1
COG0285 Folylpolyglutamate synthase.
    
  0.759
EDM45709.1
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; COG1171 Threonine dehydratase.
   
 
 0.704
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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