Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (559 aa)    
Predicted Functional Partners:
EDM44066.1
Isochorismate synthase entC; COG0147 Anthranilate/para-aminobenzoate synthases component I.
 
 0.991
EDM43969.1
Chloromuconate cycloisomerase; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily.
 
  
 0.964
menB
Naphthoate synthase (dihydroxynaphtoic acid synthetase); Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
 0.916
EDM43971.1
Putative O-succinylbenzoate--CoA ligase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
 
  
 0.873
EDM44065.1
COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism.
 
   
 0.865
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.818
EDM44068.1
COG2996 Uncharacterized protein conserved in bacteria; Belongs to the CvfB family.
       0.685
EDM45696.1
Hydrolase, alpha/beta fold family, putative; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
 
 
 0.665
EDM45085.1
Hydrolase, alpha/beta fold family protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
  
 
 0.569
EDM45526.1
COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
  
 
 0.569
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.