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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDM44117.1Hypothetical protein; COG0457 FOG: TPR repeat. (419 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      0.834
ribB
Bifunctional protein: GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.666
EDM44781.1
COG0457 FOG: TPR repeat.
  
     0.602
EDM45603.1
Hypothetical protein; COG3577 Predicted aspartyl protease.
  
     0.556
EDM44851.1
Hypothetical protein.
  
     0.524
EDM45274.1
Putative peptidase; COG4942 Membrane-bound metallopeptidase.
   
   0.514
EDM43338.1
Hypothetical protein; COG0457 FOG: TPR repeat.
 
   
 0.496
EDM45203.1
Hypothetical protein.
  
     0.496
EDM43287.1
Hypothetical protein.
  
     0.495
EDM45221.1
COG0642 Signal transduction histidine kinase.
     
 0.491
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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