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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDM44588.1COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (896 aa)    
Predicted Functional Partners:
EDM44590.1
DNA topoisomerase IV, subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit.
 0.996
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 0.987
EDM44589.1
DNA topoisomerase IV subunit B.
       0.732
secD
Protein-export membrane protein SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.712
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.662
argS-2
COG0018 Arginyl-tRNA synthetase.
 
  
 0.600
nusA
Transcription elongation factor NusA; Participates in both transcription termination and antitermination.
  
  
 0.540
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.537
EDM44443.1
Amidophosphoribosyltransferase; COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase.
 
     0.506
mscL-2
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
       0.505
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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