STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EDM44741.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (453 aa)    
Predicted Functional Partners:
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
 
 0.993
EDM44743.1
COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.
 
0.991
EDM44844.1
Arginine/ornithine transport system ATPase; COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family.
 
 0.978
EDM45302.1
COG0346 Lactoylglutathione lyase and related lyases.
 
  
 0.946
EDM43787.1
Putative acetyl-CoA hydrolase/transferase; COG0427 Acetyl-CoA hydrolase.
    
 0.803
EDM44298.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.796
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
     
 0.795
EDM43846.1
COG0372 Citrate synthase; Belongs to the citrate synthase family.
     
 0.795
sucC
succinate--CoA ligase, ADP-forming (succinyl-CoA synthetase, beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
  0.793
EDM44560.1
succinate--CoA ligase, ADP-forming (succinyl-CoA synthetase, alpha subunit); COG0074 Succinyl-CoA synthetase, alpha subunit.
    
  0.790
Your Current Organism:
unidentified eubacterium SCB49
NCBI taxonomy Id: 50743
Other names: u. eubacterium SCB49
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