node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMD00658.1 | queC | LOKO_01590 | LOKO_01588 | 6-pyruvoyl tetrahydropterin synthase. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.989 |
AMD00658.1 | queE | LOKO_01590 | LOKO_01589 | 6-pyruvoyl tetrahydropterin synthase. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.987 |
AMD00658.1 | queF | LOKO_01590 | LOKO_02644 | 6-pyruvoyl tetrahydropterin synthase. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.846 |
AMD00658.1 | tgt | LOKO_01590 | LOKO_00248 | 6-pyruvoyl tetrahydropterin synthase. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.416 |
AMD01701.1 | drrA_2 | LOKO_02642 | LOKO_02646 | Putative thioesterase. | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA. | 0.870 |
AMD01701.1 | queF | LOKO_02642 | LOKO_02644 | Putative thioesterase. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.870 |
AMD01701.1 | yadH_2 | LOKO_02642 | LOKO_02645 | Putative thioesterase. | Inner membrane transport permease YadH. | 0.870 |
AMD01701.1 | ydjA | LOKO_02642 | LOKO_02643 | Putative thioesterase. | Putative NAD(P)H nitroreductase YdjA. | 0.893 |
drrA_2 | AMD01701.1 | LOKO_02646 | LOKO_02642 | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA. | Putative thioesterase. | 0.870 |
drrA_2 | queF | LOKO_02646 | LOKO_02644 | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.877 |
drrA_2 | yadH_2 | LOKO_02646 | LOKO_02645 | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA. | Inner membrane transport permease YadH. | 0.984 |
drrA_2 | ydjA | LOKO_02646 | LOKO_02643 | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA. | Putative NAD(P)H nitroreductase YdjA. | 0.874 |
queC | AMD00658.1 | LOKO_01588 | LOKO_01590 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 6-pyruvoyl tetrahydropterin synthase. | 0.989 |
queC | queE | LOKO_01588 | LOKO_01589 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.998 |
queC | queF | LOKO_01588 | LOKO_02644 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.986 |
queC | tgt | LOKO_01588 | LOKO_00248 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.491 |
queE | AMD00658.1 | LOKO_01589 | LOKO_01590 | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 6-pyruvoyl tetrahydropterin synthase. | 0.987 |
queE | queC | LOKO_01589 | LOKO_01588 | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.998 |
queE | queF | LOKO_01589 | LOKO_02644 | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.912 |
queE | tgt | LOKO_01589 | LOKO_00248 | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.423 |