STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnDUTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (940 aa)    
Predicted Functional Partners:
Cseg_2256
PFAM: nitrogen regulatory protein P-II; KEGG: ccs:CCNA_02046 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.965
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
 
   
 0.782
Cseg_1636
PFAM: nitrogen regulatory protein P-II; KEGG: ccs:CCNA_01400 nitrogen regulatory protein GlnK; Belongs to the P(II) protein family.
 
 
 
 0.658
Cseg_4092
KEGG: ccs:CCNA_03722 glutamate synthase (NADPH) large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein.
     
 0.655
Cseg_3059
PFAM: nitrogen regulatory protein P-II; KEGG: pzu:PHZ_c1361 nitrogen regulatory protein P-II-2; Belongs to the P(II) protein family.
 
 
 
 0.642
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
       0.636
Cseg_0400
PFAM: nitrogen regulatory protein P-II; KEGG: ccs:CCNA_00555 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.627
Cseg_1981
Signal transduction histidine kinase, nitrogen specific, NtrB; KEGG: ccs:CCNA_01814 nitrogen regulation protein NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein.
  
 
 
 0.585
bamA
Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.561
Cseg_1635
KEGG: ccs:CCNA_01399 ammonium transporter/methylammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter.
 
   
 0.503
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.