node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cseg_1322 | Cseg_1898 | Cseg_1322 | Cseg_1898 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.725 |
Cseg_1322 | Cseg_2012 | Cseg_1322 | Cseg_2012 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.725 |
Cseg_1322 | Cseg_4092 | Cseg_1322 | Cseg_4092 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | KEGG: ccs:CCNA_03722 glutamate synthase (NADPH) large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein. | 0.676 |
Cseg_1322 | ilvC | Cseg_1322 | Cseg_1300 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.994 |
Cseg_1322 | ilvD | Cseg_1322 | Cseg_0716 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: ccs:CCNA_03139 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.908 |
Cseg_1322 | ilvE | Cseg_1322 | Cseg_0565 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.624 |
Cseg_1322 | leuA | Cseg_1322 | Cseg_1462 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.967 |
Cseg_1322 | leuC | Cseg_1322 | Cseg_3958 | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.856 |
Cseg_1345 | Cseg_1898 | Cseg_1345 | Cseg_1898 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.913 |
Cseg_1345 | Cseg_2012 | Cseg_1345 | Cseg_2012 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.913 |
Cseg_1345 | Cseg_4092 | Cseg_1345 | Cseg_4092 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | KEGG: ccs:CCNA_03722 glutamate synthase (NADPH) large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein. | 0.991 |
Cseg_1345 | ilvD | Cseg_1345 | Cseg_0716 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: ccs:CCNA_03139 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.913 |
Cseg_1345 | ilvE | Cseg_1345 | Cseg_0565 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.926 |
Cseg_1345 | leuA | Cseg_1345 | Cseg_1462 | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.917 |
Cseg_1898 | Cseg_1322 | Cseg_1898 | Cseg_1322 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | KEGG: ccs:CCNA_02185 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. | 0.725 |
Cseg_1898 | Cseg_1345 | Cseg_1898 | Cseg_1345 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: ccs:CCNA_02164 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.913 |
Cseg_1898 | Cseg_2012 | Cseg_1898 | Cseg_2012 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.900 |
Cseg_1898 | Cseg_4092 | Cseg_1898 | Cseg_4092 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | KEGG: ccs:CCNA_03722 glutamate synthase (NADPH) large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein. | 0.833 |
Cseg_1898 | ilvC | Cseg_1898 | Cseg_1300 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.974 |
Cseg_1898 | ilvD | Cseg_1898 | Cseg_0716 | KEGG: ccs:CCNA_01488 galactonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: ccs:CCNA_03139 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.909 |