STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cseg_1074Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; KEGG: ccs:CCNA_02704 NADP-dependent malic enzyme; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase. (762 aa)    
Predicted Functional Partners:
Cseg_1968
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.982
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.973
Cseg_1380
TIGRFAM: pyruvate kinase; KEGG: ccs:CCNA_02130 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
  
 0.972
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.970
pdhA
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.968
Cseg_0131
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; KEGG: ccs:CCNA_03663 NADP-dependent malic enzyme; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase.
 
 
0.951
Cseg_3088
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: cak:Caul_1358 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding.
   
 0.949
Cseg_1949
TIGRFAM: pyruvate, phosphate dikinase; KEGG: ccs:CCNA_01538 pyruvate phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; Belongs to the PEP-utilizing enzyme family.
  
 
 0.947
lldD
FMN-dependent alpha-hydroxy acid dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
    
 0.941
lldD-2
FMN-dependent alpha-hydroxy acid dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
    
 0.941
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.