STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (429 aa)    
Predicted Functional Partners:
Cseg_1156
TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; KEGG: ccs:CCNA_02616 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
 
 0.997
Cseg_4055
TIGRFAM: maleylacetoacetate isomerase; KEGG: ccs:CCNA_03683 maleylpyruvate isomerase; PFAM: Glutathione S-transferase domain.
 
 
 0.992
Cseg_1158
PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ccs:CCNA_02614 fumarylacetoacetase.
 
  
 0.940
Cseg_2596
TIGRFAM: phenylalanine-4-hydroxylase; KEGG: ccs:CCNA_01684 phenylalanine-4-hydroxylase; PFAM: Aromatic amino acid hydroxylase-like.
 
  
 0.900
Cseg_1159
PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: ccs:CCNA_02613 Rieske (2Fe-2S) domain protein.
 
     0.806
Cseg_0191
PFAM: transcriptional coactivator/pterin dehydratase; KEGG: ccs:CCNA_00245 pterin-4-alpha-carbinolamine dehydratase.
 
  
 0.769
Cseg_2982
KEGG: pla:Plav_0539 hypothetical protein.
  
 
 0.755
Cseg_2983
KEGG: pla:Plav_0538 hypothetical protein.
  
 
 0.755
Cseg_4054
PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ccs:CCNA_03682 fumarylpyruvate hydrolase.
  
  
 0.735
Cseg_1742
5-carboxymethyl-2-hydroxymuconate Delta-isomerase; KEGG: bbt:BBta_5587 putative enzyme with isomerase/decarboxylase activity; PFAM: fumarylacetoacetate (FAA) hydrolase.
  
  
 0.588
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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