| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cseg_0047 | Cseg_1635 | Cseg_0047 | Cseg_1635 | Siroheme synthase; KEGG: ccs:CCNA_00024 uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; TIGRFAM: siroheme synthase; PFAM: Sirohaem synthase, dimerisation domain. | KEGG: ccs:CCNA_01399 ammonium transporter/methylammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter. | 0.471 |
| Cseg_0047 | hppA | Cseg_0047 | Cseg_1663 | Siroheme synthase; KEGG: ccs:CCNA_00024 uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; TIGRFAM: siroheme synthase; PFAM: Sirohaem synthase, dimerisation domain. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.440 |
| Cseg_0047 | ppa | Cseg_0047 | Cseg_0026 | Siroheme synthase; KEGG: ccs:CCNA_00024 uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; TIGRFAM: siroheme synthase; PFAM: Sirohaem synthase, dimerisation domain. | Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.449 |
| Cseg_1635 | Cseg_0047 | Cseg_1635 | Cseg_0047 | KEGG: ccs:CCNA_01399 ammonium transporter/methylammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter. | Siroheme synthase; KEGG: ccs:CCNA_00024 uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; TIGRFAM: siroheme synthase; PFAM: Sirohaem synthase, dimerisation domain. | 0.471 |
| Cseg_1635 | hppA | Cseg_1635 | Cseg_1663 | KEGG: ccs:CCNA_01399 ammonium transporter/methylammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.439 |
| Cseg_1662 | hppA | Cseg_1662 | Cseg_1663 | KEGG: ccs:CCNA_01424 hypothetical protein. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.445 |
| Cseg_1662 | nrdR | Cseg_1662 | Cseg_1658 | KEGG: ccs:CCNA_01424 hypothetical protein. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.425 |
| Cseg_1662 | nusB | Cseg_1662 | Cseg_1660 | KEGG: ccs:CCNA_01424 hypothetical protein. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.569 |
| Cseg_1662 | ribH | Cseg_1662 | Cseg_1659 | KEGG: ccs:CCNA_01424 hypothetical protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.569 |
| Cseg_1662 | thiL | Cseg_1662 | Cseg_1661 | KEGG: ccs:CCNA_01424 hypothetical protein. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.569 |
| glyA | hppA | Cseg_1657 | Cseg_1663 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.405 |
| glyA | nrdR | Cseg_1657 | Cseg_1658 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.645 |
| glyA | nusB | Cseg_1657 | Cseg_1660 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.601 |
| glyA | ppa | Cseg_1657 | Cseg_0026 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.460 |
| glyA | ribH | Cseg_1657 | Cseg_1659 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.572 |
| glyA | thiL | Cseg_1657 | Cseg_1661 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.544 |
| hppA | Cseg_0047 | Cseg_1663 | Cseg_0047 | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Siroheme synthase; KEGG: ccs:CCNA_00024 uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase; TIGRFAM: siroheme synthase; PFAM: Sirohaem synthase, dimerisation domain. | 0.440 |
| hppA | Cseg_1635 | Cseg_1663 | Cseg_1635 | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | KEGG: ccs:CCNA_01399 ammonium transporter/methylammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter. | 0.439 |
| hppA | Cseg_1662 | Cseg_1663 | Cseg_1662 | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | KEGG: ccs:CCNA_01424 hypothetical protein. | 0.445 |
| hppA | glyA | Cseg_1663 | Cseg_1657 | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.405 |
