STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rutAPyrimidine utilization protein A; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. (352 aa)    
Predicted Functional Partners:
rutB
Pyrimidine utilization protein B; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily.
 
 
  0.991
Cseg_1790
PFAM: isochorismatase hydrolase; KEGG: cak:Caul_1793 isochorismatase hydrolase.
 
 
  0.944
Cseg_1730
KEGG: bxe:Bxe_A1380 putative oxygenase; manually curated; PFAM: flavin reductase domain protein FMN-binding.
 
 
 0.935
Cseg_1789
PFAM: Luciferase-like, subgroup; KEGG: ccs:CCNA_01227 nitrilotriacetate monooxygenase.
  
  
 
0.913
rutD
Pyrimidine utilization protein D; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
 
    0.905
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
  0.900
rutC
Pyrimidine utilization protein C; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation.
 
    0.894
Cseg_2077
PFAM: Tetracycline transcriptional regulator YcdC domain protein; regulatory protein TetR; KEGG: ccs:CCNA_02884 transcriptional regulator, TetR family.
 
     0.682
Cseg_2022
TIGRFAM: aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein; PFAM: NMT1/THI5 like domain protein; KEGG: swi:Swit_2508 aliphatic sulfonate ABC transporter periplasmic ligand-binding protein; SMART: extracellular solute-binding protein family 3.
 
  
 0.571
Cseg_2031
KEGG: cak:Caul_2662 extracellular solute-binding protein; PFAM: extracellular solute-binding protein family 3; SMART: extracellular solute-binding protein family 3.
 
  
 0.537
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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