STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cseg_2914KpsF/GutQ family protein; SMART: CBS domain containing protein; TIGRFAM: KpsF/GutQ family protein; KEGG: ccs:CCNA_02346 arabinose-5-phosphate isomerase; PFAM: sugar isomerase (SIS); CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. (318 aa)    
Predicted Functional Partners:
kdsA
TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; KEGG: ccs:CCNA_01496 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA.
 
 
 0.991
Cseg_3427
TIGRFAM: 3-deoxy-D-manno-octulosonate cytidylyltransferase; KEGG: ccs:CCNA_03029 3-deoxy-manno-octulosonate cytidylyltransferase; PFAM: acylneuraminate cytidylyltransferase.
 
   
 0.905
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.899
Cseg_3854
Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
   
 0.895
Cseg_2196
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.892
lpxA
acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.888
lpxC
UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
   
 0.884
lpxD
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
  
 0.875
Cseg_2901
PFAM: lipid A biosynthesis acyltransferase; KEGG: ccs:CCNA_02333 lipid A biosynthesis lauroyl acyltransferase.
 
   
 0.835
Cseg_2913
KEGG: ccs:CCNA_02345 hypothetical protein.
       0.791
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.