Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
nikRNickel responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (156 aa)    
Predicted Functional Partners:
hypB
Hydrogenase nickel incorporation protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.604
cybH
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.499
exbB-2
Energy transducer TonB; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.481
KGL31731.1
Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.463
nikA
Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.437
exbD
Biopolymer transporter ExbD; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.425
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
     
 0.414
ureA
Urease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the urease beta subunit family.
     
 0.411
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.407
Your Current Organism:
Helicobacter trogontum
NCBI taxonomy Id: 50960
Other names: ATCC 700114, CCUG 49050, Flexispira taxon 6, H. trogontum, Helicobacter sp. ATCC 43966, Helicobacter sp. ATCC 43968, Helicobacter sp. ATCC 49310, LRB 8581
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