node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APN2 | FEN1 | A0A507QKY5 | A0A507QU82 | Class II abasic (AP) endonuclease. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.855 |
APN2 | MPDQ_001917 | A0A507QKY5 | A0A507QLI5 | Class II abasic (AP) endonuclease. | AP_endonuc_2 domain-containing protein. | 0.980 |
APN2 | MPDQ_003103 | A0A507QKY5 | A0A507R3N9 | Class II abasic (AP) endonuclease. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.876 |
APN2 | NTHL1 | A0A507QKY5 | A0A507QW95 | Class II abasic (AP) endonuclease. | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. | 0.890 |
APN2 | OGG1 | A0A507QKY5 | A0A507QR51 | Class II abasic (AP) endonuclease. | 8-oxoguanine glycosylase ogg1. | 0.835 |
APN2 | SMD1 | A0A507QKY5 | A0A507R656 | Class II abasic (AP) endonuclease. | Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. | 0.857 |
APN2 | SMD2 | A0A507QKY5 | A0A507R414 | Class II abasic (AP) endonuclease. | Small nuclear ribonucleoprotein Sm D2. | 0.835 |
APN2 | SMD3 | A0A507QKY5 | A0A507QGM2 | Class II abasic (AP) endonuclease. | Small nuclear ribonucleoprotein Sm D3. | 0.867 |
APN2 | SME1 | A0A507QKY5 | A0A507R0B0 | Class II abasic (AP) endonuclease. | Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. | 0.822 |
APN2 | SMG1 | A0A507QKY5 | A0A507QP31 | Class II abasic (AP) endonuclease. | Small nuclear ribonucleoprotein G. | 0.812 |
FEN1 | APN2 | A0A507QU82 | A0A507QKY5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Class II abasic (AP) endonuclease. | 0.855 |
FEN1 | MPDQ_001917 | A0A507QU82 | A0A507QLI5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AP_endonuc_2 domain-containing protein. | 0.618 |
FEN1 | MPDQ_003103 | A0A507QU82 | A0A507R3N9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.999 |
FEN1 | NTHL1 | A0A507QU82 | A0A507QW95 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. | 0.713 |
FEN1 | OGG1 | A0A507QU82 | A0A507QR51 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 8-oxoguanine glycosylase ogg1. | 0.625 |
MPDQ_001917 | APN2 | A0A507QLI5 | A0A507QKY5 | AP_endonuc_2 domain-containing protein. | Class II abasic (AP) endonuclease. | 0.980 |
MPDQ_001917 | FEN1 | A0A507QLI5 | A0A507QU82 | AP_endonuc_2 domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.618 |
MPDQ_001917 | NTHL1 | A0A507QLI5 | A0A507QW95 | AP_endonuc_2 domain-containing protein. | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. | 0.843 |
MPDQ_001917 | OGG1 | A0A507QLI5 | A0A507QR51 | AP_endonuc_2 domain-containing protein. | 8-oxoguanine glycosylase ogg1. | 0.666 |
MPDQ_003103 | APN2 | A0A507R3N9 | A0A507QKY5 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Class II abasic (AP) endonuclease. | 0.876 |