STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NECAME_15419alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (487 aa)    
Predicted Functional Partners:
NECAME_05424
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
  
 
0.967
NECAME_08155
Glycosyl hydrolase, family 31; Belongs to the glycosyl hydrolase 31 family.
   
 
 0.922
NECAME_10037
Putative glycerol kinase.
 
      0.699
NECAME_10496
Mannosyltransferase.
   
  
 0.660
NECAME_09703
Calreticulin family protein.
      
 0.650
NECAME_10306
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]
   
  
 0.647
NECAME_17235
Uncharacterized protein.
      
 0.646
NECAME_06182
Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
    
 
 0.646
NECAME_06760
Mannosyltransferase.
      
 0.641
NECAME_15282
Uncharacterized protein.
      
 0.635
Your Current Organism:
Necator americanus
NCBI taxonomy Id: 51031
Other names: N. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.