STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NECAME_14496Uncharacterized protein. (157 aa)    
Predicted Functional Partners:
NECAME_14497
Tyrosyl-DNA phosphodiesterase.
 
     0.899
NECAME_05433
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.848
NECAME_11976
Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region.
    
 
 0.728
NECAME_01378
Ku70/Ku80 beta-barrel domain protein.
     
 0.718
NECAME_01737
ERCC4 domain protein.
   
 
 0.706
NECAME_00797
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
   
 
 0.665
NECAME_16880
DNA ligase.
   
 
 0.596
NECAME_16881
DNA ligase domain protein.
   
 
 0.596
NECAME_17486
Uncharacterized protein.
   
 
 0.595
NECAME_14498
Ulp1 protease family, catalytic domain protein.
 
      0.573
Your Current Organism:
Necator americanus
NCBI taxonomy Id: 51031
Other names: N. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.