STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NECAME_19074Malic enzyme, NAD binding domain protein. (84 aa)    
Predicted Functional Partners:
NECAME_00358
Malate synthase A.
  
 
 0.937
NECAME_12819
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.562
NECAME_03476
AMP-binding enzyme.
  
 0.544
NECAME_13160
Thiamine pyrophosphate enzyme, TPP binding domain protein; Belongs to the TPP enzyme family.
  
 
 0.539
NECAME_12882
Thiamine pyrophosphate enzyme, TPP binding domain protein; Belongs to the TPP enzyme family.
  
 
 0.539
NECAME_10391
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.538
NECAME_10328
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
  
  
 0.535
NECAME_18591
Malic domain-containing protein.
  
     0.529
NECAME_11547
AMP-binding domain-containing protein.
  
 0.524
NECAME_02578
Lyase_1 domain-containing protein.
  
 
 0.503
Your Current Organism:
Necator americanus
NCBI taxonomy Id: 51031
Other names: N. americanus
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