STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NECAME_13710Zinc finger, C3HC4 type. (362 aa)    
Predicted Functional Partners:
NECAME_03820
Small ubiquitin-related modifier.
    
 0.737
NECAME_13099
Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.687
NECAME_07851
Uncharacterized protein.
    
 0.687
NECAME_02210
Ubiquitin-like domain-containing protein.
    
 0.655
NECAME_05433
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.631
NECAME_04826
PAN domain protein.
    
 0.610
NECAME_18637
Uncharacterized protein.
    
 0.610
NECAME_06183
WD domain, G-beta repeat protein.
      
 0.597
NECAME_03134
Putative potassium voltage-gated channel protein Shal; Belongs to the potassium channel family.
      
 0.566
NECAME_12161
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
      
 0.553
Your Current Organism:
Necator americanus
NCBI taxonomy Id: 51031
Other names: N. americanus
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