STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NECAME_07577RPA_C domain-containing protein. (293 aa)    
Predicted Functional Partners:
NECAME_02538
Replication factor-A domain protein.
   
 0.985
NECAME_02537
Uncharacterized protein.
   
 0.985
NECAME_08039
DUF1767 domain-containing protein.
   
 0.983
NECAME_07595
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.974
NECAME_01051
Eukaryotic-type DNA primase, large subunit.
   
 0.967
NECAME_15697
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 0.959
NECAME_06189
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.955
NECAME_05184
DNA repair protein.
    
 0.945
NECAME_17421
DNA polymerase epsilon subunit B.
   
 0.931
NECAME_15211
DNA helicase; Belongs to the MCM family.
   
 0.923
Your Current Organism:
Necator americanus
NCBI taxonomy Id: 51031
Other names: N. americanus
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