STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
creADNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. (429 aa)    
Predicted Functional Partners:
creB
Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
    
 
 0.985
xlnR
Xylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'.
    
 0.984
creC
Probable catabolite repression protein creC; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways (By similarity); Belongs to the WD repeat creC family.
    
 0.982
pacC
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family.
    
 
 0.966
creD
Probable HECT-type ubiquitin ligase-interacting protein creD; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability (By similarity).
    
 
 0.907
laeA
Secondary metabolism regulator laeA; Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the kojic acid gene cluster, producing a secondary metabolite used as a skin-lightening agent, an antioxidant, and an antibiotic.
    
 0.816
hulA
Probable E3 ubiquitin-protein ligase hulA; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.
    
 0.791
AO090701000767
Non-specific serine/threonine protein kinase.
    
 0.779
xlnD
Exo-1,4-beta-xylosidase xlnD; Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
    
 
 0.775
act1
Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family.
    
 0.769
Your Current Organism:
Aspergillus oryzae
NCBI taxonomy Id: 510516
Other names: A. oryzae RIB40, Aspergillus oryzae RIB40
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