| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AO090701000767 | creA | Q2U7N6 | Q9P889 | Non-specific serine/threonine protein kinase. | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | 0.779 |
| act1 | creA | Q2U7A3 | Q9P889 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | 0.769 |
| act1 | laeA | Q2U7A3 | Q2ULA2 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Secondary metabolism regulator laeA; Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the kojic acid gene cluster, producing a secondary metabolite used as a skin-lightening agent, an antioxidant, and an antibiotic. | 0.434 |
| act1 | xlnR | Q2U7A3 | Q2UD93 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Xylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'. | 0.500 |
| creA | AO090701000767 | Q9P889 | Q2U7N6 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Non-specific serine/threonine protein kinase. | 0.779 |
| creA | act1 | Q9P889 | Q2U7A3 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | 0.769 |
| creA | creB | Q9P889 | Q2UUG8 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | 0.985 |
| creA | creC | Q9P889 | Q2UM42 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Probable catabolite repression protein creC; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways (By similarity); Belongs to the WD repeat creC family. | 0.982 |
| creA | creD | Q9P889 | Q2UM46 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Probable HECT-type ubiquitin ligase-interacting protein creD; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability (By similarity). | 0.907 |
| creA | hulA | Q9P889 | Q2UBP1 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Probable E3 ubiquitin-protein ligase hulA; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. | 0.791 |
| creA | laeA | Q9P889 | Q2ULA2 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Secondary metabolism regulator laeA; Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the kojic acid gene cluster, producing a secondary metabolite used as a skin-lightening agent, an antioxidant, and an antibiotic. | 0.816 |
| creA | pacC | Q9P889 | Q9HFB3 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family. | 0.966 |
| creA | xlnD | Q9P889 | Q2UR38 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Exo-1,4-beta-xylosidase xlnD; Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. | 0.775 |
| creA | xlnR | Q9P889 | Q2UD93 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Xylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'. | 0.984 |
| creB | creA | Q2UUG8 | Q9P889 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. | 0.985 |
| creB | creC | Q2UUG8 | Q2UM42 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | Probable catabolite repression protein creC; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways (By similarity); Belongs to the WD repeat creC family. | 0.999 |
| creB | creD | Q2UUG8 | Q2UM46 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | Probable HECT-type ubiquitin ligase-interacting protein creD; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability (By similarity). | 0.945 |
| creB | hulA | Q2UUG8 | Q2UBP1 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | Probable E3 ubiquitin-protein ligase hulA; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. | 0.855 |
| creB | pacC | Q2UUG8 | Q9HFB3 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family. | 0.484 |
| creB | xlnD | Q2UUG8 | Q2UR38 | Probable ubiquitin carboxyl-terminal hydrolase creB; Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity). | Exo-1,4-beta-xylosidase xlnD; Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. | 0.609 |