CSE_02270 protein (Caldisericum exile) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CSE_02270

Oxidoreductase FAD binding subunit. (291 aa)

Predicted Functional Partners:

CSE_02280

0.998

CSE_02240

0.997

CSE_07200

0.993

CSE_06760

0.986

CSE_07190

0.986

CSE_06770

0.984

CSE_02260

0.963

ade

0.919

CSE_07180

0.917

hpt

0.900

Your Current Organism:

Caldisericum exile

NCBI taxonomy Id: 511051
Other names: C. exile AZM16c01, Caldisericum exile AZM16c01, filamentous bacterium AZM16c01

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSE_02240	CSE_02260	CSE_02240	CSE_02260	Oxidoreductase iron-sulfur binding subunit.	XdhC_CoxI family protein.	0.935
CSE_02240	CSE_02270	CSE_02240	CSE_02270	Oxidoreductase iron-sulfur binding subunit.	Oxidoreductase FAD binding subunit.	0.997
CSE_02240	CSE_02280	CSE_02240	CSE_02280	Oxidoreductase iron-sulfur binding subunit.	Oxidoreductase molybdopterin-binding subunit.	0.998
CSE_02240	CSE_06760	CSE_02240	CSE_06760	Oxidoreductase iron-sulfur binding subunit.	Oxidoreductase molybdopterin-binding subunit.	0.992
CSE_02240	CSE_07180	CSE_02240	CSE_07180	Oxidoreductase iron-sulfur binding subunit.	Oxidoreductase FAD binding subunit.	0.987
CSE_02240	CSE_07200	CSE_02240	CSE_07200	Oxidoreductase iron-sulfur binding subunit.	Oxidoreductase molybdopterin-binding subunit.	0.994
CSE_02260	CSE_02240	CSE_02260	CSE_02240	XdhC_CoxI family protein.	Oxidoreductase iron-sulfur binding subunit.	0.935
CSE_02260	CSE_02270	CSE_02260	CSE_02270	XdhC_CoxI family protein.	Oxidoreductase FAD binding subunit.	0.963
CSE_02260	CSE_02280	CSE_02260	CSE_02280	XdhC_CoxI family protein.	Oxidoreductase molybdopterin-binding subunit.	0.956
CSE_02260	CSE_06760	CSE_02260	CSE_06760	XdhC_CoxI family protein.	Oxidoreductase molybdopterin-binding subunit.	0.787
CSE_02260	CSE_06770	CSE_02260	CSE_06770	XdhC_CoxI family protein.	Oxidoreductase iron-sulfur binding subunit.	0.729
CSE_02260	CSE_07180	CSE_02260	CSE_07180	XdhC_CoxI family protein.	Oxidoreductase FAD binding subunit.	0.882
CSE_02260	CSE_07190	CSE_02260	CSE_07190	XdhC_CoxI family protein.	Oxidoreductase iron-sulfur binding subunit.	0.745
CSE_02260	CSE_07200	CSE_02260	CSE_07200	XdhC_CoxI family protein.	Oxidoreductase molybdopterin-binding subunit.	0.803
CSE_02270	CSE_02240	CSE_02270	CSE_02240	Oxidoreductase FAD binding subunit.	Oxidoreductase iron-sulfur binding subunit.	0.997
CSE_02270	CSE_02260	CSE_02270	CSE_02260	Oxidoreductase FAD binding subunit.	XdhC_CoxI family protein.	0.963
CSE_02270	CSE_02280	CSE_02270	CSE_02280	Oxidoreductase FAD binding subunit.	Oxidoreductase molybdopterin-binding subunit.	0.998
CSE_02270	CSE_06760	CSE_02270	CSE_06760	Oxidoreductase FAD binding subunit.	Oxidoreductase molybdopterin-binding subunit.	0.986
CSE_02270	CSE_06770	CSE_02270	CSE_06770	Oxidoreductase FAD binding subunit.	Oxidoreductase iron-sulfur binding subunit.	0.984
CSE_02270	CSE_07180	CSE_02270	CSE_07180	Oxidoreductase FAD binding subunit.	Oxidoreductase FAD binding subunit.	0.917

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.852

expected number of edges:

14

PPI enrichment p-value:

4.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 23

1.94

1.8

0.00021

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004775

succinate-CoA ligase (ADP-forming) activity

3 of 4

2.57

2.05

0.00016

GO:0016874

Ligase activity

4 of 148

1.13

0.64

0.0245

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045239

Tricarboxylic acid cycle enzyme complex

3 of 5

2.47

2.29

4.96e-05

GO:0009361

succinate-CoA ligase complex (ADP-forming)

2 of 3

2.52

1.4

0.0027

GO:1902494

Catalytic complex

3 of 104

1.15

0.62

0.0323

GO:0032991

Protein-containing complex

4 of 232

0.93

0.53

0.0323

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7774

succinate-CoA ligase complex, and Purine catabolism PurC-like domain

5 of 5

2.69

4.6

1.88e-09

CL:7705

Aromatic compound catabolic process, and PucR C-terminal helix-turn-helix domain

7 of 45

1.89

3.55

1.88e-09

CL:7712

Mixed, incl. Aldehyde oxidase/xanthine dehydrogenase, and Molybdopterin dehydrogenase, FAD-binding

2 of 7

2.15

0.88

0.0236

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

4 of 6

2.52

3.27

5.90e-07

GOCC:0042709

succinate-CoA ligase complex

3 of 4

2.57

2.4

3.36e-05

GOCC:0009361

succinate-CoA ligase complex (ADP-forming)

2 of 3

2.52

1.31

0.0039

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00549

CoA-ligase

2 of 3

2.52

0.86

0.0267

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