STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiCProbable crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle (517 aa)    
Predicted Functional Partners:
caiD
Carnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
 0.994
caiA
Crotonobetainyl-CoA reductase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA. The electron donor could be the FixA/FixB complex
  
 0.971
caiB
L-carnitine CoA-transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA; Belongs to the CaiB/BaiF CoA-transferase family
  
 0.970
fixB
Protein FixB; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF alpha-subunit/FixB family
 
  
 0.943
fixC
Protein FixC; Could be part of an electron transfer system required for anaerobic carnitine reduction
 
   
 0.917
caiE
Carnitine operon protein CaiE; Overproduction of CaiE stimulates the activity of CaiB and CaiD
     
 0.913
fixA
Protein FixA; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF beta-subunit/FixA family
 
   
 0.913
caiT
L-carnitine/gamma-butyrobetaine antiporter; Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines
 
   
 0.905
tag
DNA-3-methyladenine glycosylase 1; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions
      
 0.750
aes
Acetyl esterase; Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity
 
  
 0.718
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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