node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ddlA | ddlB | b0381 | b0092 | D-alanine-D-alanine ligase A; Cell wall formation. | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.919 |
ddlA | ftsI | b0381 | b0084 | D-alanine-D-alanine ligase A; Cell wall formation. | Transpeptidase involved in septal peptidoglycan synthesis; Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum. Required for localization of FtsN. Belongs to the transpeptidase family. FtsI subfamily. | 0.598 |
ddlA | ftsW | b0381 | b0089 | D-alanine-D-alanine ligase A; Cell wall formation. | Putative lipid II flippase; Peptidoglycan polymerase that is essential for cell division (Probable). Functions probably in conjunction with the penicillin- binding protein 3 (ftsI). Required for localization of FtsI. | 0.723 |
ddlA | mraY | b0381 | b0087 | D-alanine-D-alanine ligase A; Cell wall formation. | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan. | 0.832 |
ddlA | murA | b0381 | b3189 | D-alanine-D-alanine ligase A; Cell wall formation. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic fosfomycin; Belongs to the EPSP synthase family. MurA subfamily. | 0.786 |
ddlA | murC | b0381 | b0091 | D-alanine-D-alanine ligase A; Cell wall formation. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.993 |
ddlA | murD | b0381 | b0088 | D-alanine-D-alanine ligase A; Cell wall formation. | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). | 0.870 |
ddlA | murE | b0381 | b0085 | D-alanine-D-alanine ligase A; Cell wall formation. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine. | 0.799 |
ddlA | murF | b0381 | b0086 | D-alanine-D-alanine ligase A; Cell wall formation. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. | 0.993 |
ddlA | murG | b0381 | b0090 | D-alanine-D-alanine ligase A; Cell wall formation. | N-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II). | 0.848 |
ddlB | ddlA | b0092 | b0381 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanine-D-alanine ligase A; Cell wall formation. | 0.919 |
ddlB | ftsI | b0092 | b0084 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Transpeptidase involved in septal peptidoglycan synthesis; Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum. Required for localization of FtsN. Belongs to the transpeptidase family. FtsI subfamily. | 0.928 |
ddlB | ftsW | b0092 | b0089 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Putative lipid II flippase; Peptidoglycan polymerase that is essential for cell division (Probable). Functions probably in conjunction with the penicillin- binding protein 3 (ftsI). Required for localization of FtsI. | 0.982 |
ddlB | mraY | b0092 | b0087 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan. | 0.957 |
ddlB | murA | b0092 | b3189 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic fosfomycin; Belongs to the EPSP synthase family. MurA subfamily. | 0.904 |
ddlB | murC | b0092 | b0091 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.999 |
ddlB | murD | b0092 | b0088 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). | 0.991 |
ddlB | murE | b0092 | b0085 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine. | 0.978 |
ddlB | murF | b0092 | b0086 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. | 0.999 |
ddlB | murG | b0092 | b0090 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | N-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II). | 0.994 |