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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ampEAmpicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams (284 aa)    
Predicted Functional Partners:
ampD
1,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; Involved in cell wall peptidoglycan recycling . Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety . Is also involved in beta-lactamase induction
  
  
 0.989
ampC
Penicillin-binding protein; This protein is a serine beta-lactamase with a substrate specificity for cephalosporins
      
 0.875
nadC
Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA)
     
 0.779
ampG
Mfs transporter, pat family, beta-lactamase induction signal transducer ampg; Permease involved in cell wall peptidoglycan recycling . Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro- N-acetylmuramic acid (GlcNAc-anhMurNAc) and GlcNAc-anhMurNAc-peptides . Transport is dependent on the proton motive force . AmpG is also involved in beta-lactamase induction
      
 0.734
ygbE
Inner membrane protein YgbE; Putative cytochrome oxidase subunit
  
     0.732
ypfN
annotation not available
  
     0.685
ybjO
annotation not available
  
     0.652
yceB
annotation not available
  
     0.649
yniB
annotation not available
  
     0.647
ydbJ
annotation not available
  
     0.644
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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