STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligTRna 2',3'-cyclic 3'-phosphodiesterase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester . In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible (176 aa)    
Predicted Functional Partners:
sfsA
Putative dna-binding transcriptional regulator of maltose metabolism; Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism
  
  
 0.916
yfaY
IPR008135 CinA family protein YfaY; Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity
 
  
 0.910
pncC
Nicotinamide-nucleotide amidohydrolase; Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates
    
 0.806
gluQ
Glutamyl-q trna(asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in position 34 of the tRNA(Asp), the wobble position of the QUC anticodon. Does not transfer glutamate to either tRNA(Glu) or tRNA(Gln). The incapacity of the glutamylated tRNA(Asp) to bind elongation factor Tu suggests that it is not involved in ribosomal protein biosynthesis
     
 0.750
rtcB
Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases
     
 0.648
dksA
Rna polymerase-binding transcription factor dksa; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription. Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic termina [...]
     
 0.640
hrpB
Putative atp-dependent rna helicase hrpb; Helicase, ATP-dependent; Protein involved in DNA-dependent DNA replication
       0.631
ybdF
annotation not available
      
 0.608
frlD
Fructoselysine 6-kinase; Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate . Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine . To a much lesser extenst, is also able to phosphorylate psicoselysine
     
 0.608
yafD
annotation not available
      
 0.607
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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