STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nlpEInvolved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes . Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation . Functions during envelope stress responses; when overproduced induces degP through the activation of the two-component envelope stress response system CpxA/CpxR (PubMed:7635808, PubMed:15252048). DegP induction seems to require membrane anchoring of this protein . Structural changes and/or interaction of the CXXC motif with its environm [...] (236 aa)    
Predicted Functional Partners:
cpxA
Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA . Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity . The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed:16166523, PubMed:17259177, PubMed:25207645). Involved in several diverse cellular processes, including the functioning of acetohyd [...]
   
 
 0.983
cpxR
Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA . Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation . Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) . Binds and activates transcription from the degP promoter ; binding is enhanced by phosphorylation . This system combats a variety of extr [...]
   
  
 0.879
arfB
Rescues stalled ribosomes (PubMed:21418110, PubMed:21051357, PubMed:22922063). Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA . First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA) . ECO:0000269|PubMed:21418110, ECO:0000269|PubMed:22422986,
  
    0.877
cpxP
Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers . Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity . Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway . Aids in combating extracytoplasmic protein-mediated toxicity (P [...]
  
   
 0.868
yaeQ
Uncharacterized protein YaeQ; Putative enzyme; Not classified
 
     0.860
yafY
When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR
      
 0.708
yfjS
Does not induce degP when overexpressed unless it is mutated to resemble YafY
      
 0.677
rcsF
Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division. ECO:0000269|PubMed:13129944, ECO:0000269|PubMed:14651646,
  
   
 0.670
yfeY
annotation not available
  
   
 0.670
yebZ
Inner membrane protein YebZ; Putative resistance protein; Protein involved in response to drug
      
 0.648
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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