STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yafWCytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YkfI . It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism . Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells (105 aa)    
Predicted Functional Partners:
ykfI
CP4-6 prophage; toxin of the YkfI-YafW toxin-antitoxin system; Toxic component of a type IV toxin-antitoxin (TA) system . Acts as a toxin inhibitor that blocks cell division and cell elongation via FtsZ and possibly also MreB (although no interaction with MreB has been proven) . Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation These effects are overcome by concomitant expression of cognate antitoxin YafW, which leads to toxin loss by an unknown mechanism . Overexpression leads to formation of lemon-shaped cells and cell lysis; inactiv [...]
 
  
 0.995
yafX
Uncharacterized protein YafX; Phage or Prophage Related; Belongs to the antirestriction protein family
 
  
 0.990
ykfH
DUF987 domain-containing protein YkfH; Belongs to the YeeT/YkfH/YpjJ family
 
  
 0.990
ypjF
CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system; Toxic component of a type IV toxin-antitoxin (TA) system . Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Overexpression results in inhibition of growth in liquid cultures . Overexpression leads to formation of lemon-shaped cells; inactivated by overexpression of cognate antitoxin YfjZ but not when the 2 genes are coexpressed from the same plasmid . Also neutralized by overexpression of non-cognate antitoxins YafW and CbeA
  
   
 0.971
cbtA
Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...]
  
   
 0.961
ykfG
CP4-6 prophage; RadC-like JAB domain-containing protein YkfG; Belongs to the UPF0758 family
 
  
 0.955
yfjX
CP4-57 prophage; putative antirestriction protein; Belongs to the antirestriction protein family
  
  
 0.952
ypjJ
CP4-57 prophage; DUF987 domain-containing protein YpjJ; Belongs to the YeeT/YkfH/YpjJ family
  
   
 0.938
ykfF
UPF0401 protein YkfF; Phage or Prophage Related; Belongs to the UPF0401 family
 
    0.884
rnlB
CP4-57 prophage; antitoxin RnlB; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non-cognate toxin LsoA
      
 0.826
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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