STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yafXCP4-6 prophage; uncharacterized protein; Belongs to the antirestriction protein family. (152 aa)    
Predicted Functional Partners:
yafW
CP4-6 prophage; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YkfI. It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism. Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells.
  
  
 0.983
ykfH
Uncharacterized protein; Belongs to the YeeT/YkfH/YpjJ family.
  
  
 0.978
ykfG
CP4-6 prophage; Putative DNA repair protein; Belongs to the UPF0758 family.
  
  
 0.965
ykfF
CP4-6 prophage; uncharacterized protein; Belongs to the UPF0401 family.
  
  
 0.963
ykfI
Toxin YkfI; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a toxin inhibitor that blocks cell division and cell elongation via FtsZ and possibly also MreB (although no interaction with MreB has been proven). Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation. These effects are overcome by concomitant expression of cognate antitoxin YafW, which leads to toxin loss by an unknown mechanism. Overexpression leads to formation of lemon-shaped cells and cell lysis; inactivated by overexpression of cognate antitoxin YafW but [...]
  
  
 0.921
ykfB
CP4-6 prophage; uncharacterized protein; To E.coli YfjT.
  
  
 0.733
yafZ
UPF0380 protein YafZ; CP4-6 prophage; putative DNA-binding transcriptional regulator;Phage or Prophage Related; Belongs to the UPF0380 family.
  
    0.632
ulaF
L-ribulose 5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the aldolase class II family. AraD/FucA subfamily.
   
  
 0.521
yafY
Lipoprotein, inner membrane; When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR ; To E.coli YfjS.
  
    0.475
ypjJ
Uncharacterized protein; Belongs to the YeeT/YkfH/YpjJ family.
     
 0.468
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.