STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybaOPutative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine (152 aa)    
Predicted Functional Partners:
mdlA
Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family
 
  
 0.878
yjcB
annotation not available
   
  
 0.795
ybiH
Tetr/acrr family transcriptional regulator, regulator of cefoperazone and chloramphenicol sensitivity; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons
   
  
 0.793
ypeC
DUF2502 family putative periplasmic protein; To E.coli YaaX
      
 0.786
mdlB
Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family
 
  
 0.760
asnC
Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post- transcriptional level
  
   
 0.718
yhaO
Putative d/l-serine transporter; Plays a role in L-cysteine detoxification . May transport both D- and L-serine (By similarity)
      
 0.705
yhaM
Putative l-serine dehydratase alpha chain; Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase
      
 0.676
putA
Rhh-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon
     
 0.662
yphH
Putative dna-binding transcriptional regulator, nagc-like; Belongs to the ROK (NagC/XylR) family
      
 0.619
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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