STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rlmF23S rRNA m(6)A1618 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 1618 of 23S rRNA; Belongs to the methyltransferase superfamily. METTL16/RlmF family. (308 aa)    
Predicted Functional Partners:
rlmJ
23S rRNA m(6)A2030 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Required for the utilization of extracellular DNA as the sole source of carbon and energy. Belongs to the RlmJ family.
      
 0.915
rsmA
16S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Has also a DNA glycosylase/AP lyase activity that removes C mispaired with oxidized T from DNA, and may play a role in protection of DNA against oxidative stress.
   
  
 0.821
rlmG
23S rRNA m(2)G1835 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
   
  
 0.657
rlmI
23S rRNA m(5)C1962 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits; Belongs to the methyltransferase superfamily. RlmI family.
   
  
 0.648
rsmD
16S rRNA m(2)G966 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.
      
 0.643
rsmC
16S rRNA m(2)G1207 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
   
  
 0.643
trmN
tRNA1(Val) (adenine(37)-N6)-methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC); Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
   
  
 0.625
yafE
Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily.
      
 0.622
rlmL
23S rRNA m(2)G2445 and m(7)G2069 methyltransferases, SAM-dependent; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits. Belongs to the methyltransferase superfamily. RlmKL family.
   
  
 0.616
ymdB
O-acetyl-ADP-ribose deacetylase; Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation. Overexpression inhibits biofilm formation via an RNase III-independent pathway. This inhibition is RpoS-dependent. Overexpression also results in increased susceptibility to apramycin. Belongs to the YmdB family.
 
 
    0.606
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.