STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgaCPoly-n-acetyl-d-glucosamine synthase subunit pgac; Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide (441 aa)    
Predicted Functional Partners:
pgaD
Poly-n-acetyl-d-glucosamine synthase subunit pgad; Required for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase PgaC in the polymerization of PGA
  
 0.999
pgaA
Exports the biofilm adhesin polysaccharide poly-beta-1,6-N- acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N-deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin
 
  
 0.998
pgaB
poly-beta-1,6-N-acetyl-D-glucosamine (PGA) N-deacetylase outer membrane export lipoprotein; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin
 
  
 0.991
wcaD
Putative colanic acid polymerase; Putative enzyme; Phage-related functions and prophages
  
   
 0.765
yadE
Putative polysaccharide deacetylase lipoprotein; Uncharacterized protein YadE
 
  
 0.692
bcsB
Regulator of cellulose synthase, cyclic di-gmp binding; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
      
 0.680
damX
Cell division protein that binds to the septal ring; Non-essential cell division protein
   
 
 0.635
yfaL
Putative autotransporter adhesin yfal; Probably an autotransporter
      
 0.583
csrA
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability, initially identified for its effects on central carbon metabolism . Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems . Binds to the 5'-UTR of mRNA to repress or activate translation; 2 binding sites on the homodimer can bridge 2 sites within target RNA (By similarity). Exerts reciprocal effects on enzymes of gluconeogenesis and glycogen biosynthesis versus [...]
      
 0.560
csrD
Targeting factor for csrbc srna degradation; Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di-GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression
     
 0.528
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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