STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mppAMurein tripeptide (l-ala-gamma-d-glutamyl-meso-dap) transporter subunit; Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system (537 aa)    
Predicted Functional Partners:
oppB
Murein tripeptide abc transporter/oligopeptide abc transporter inner membrane subunit oppb; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
 
 0.981
oppC
Murein tripeptide abc transporter/oligopeptide abc transporter inner membrane subunit oppc; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
 
 0.981
oppF
Murein tripeptide abc transporter/oligopeptide abc transporter atp binding subunit oppf; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
 
 
 0.977
oppD
Murein tripeptide abc transporter/oligopeptide abc transporter atp binding subunit oppd; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
 
 0.973
oppA
Oligopeptide abc transporter periplasmic binding protein; This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity
  
 
0.831
mpaA
Murein tripeptide amidase a; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap . Has weak activity with L-Ala- gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap . Cannot hydrolyze murein tetrapeptide
  
  
 0.826
dppC
Dipeptide abc transporter membrane subunit dppc; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
 
 
 0.750
dppB
Dipeptide abc transporter membrane subunit dppb; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
 
 
 0.724
ycjY
Putative hydrolase ycjy; Uncharacterized protein YcjY; Pseudogene fragment, MhpC family
  
  
 0.714
pgrR
Lysr family transcriptional regulator, regulator of peptidoglycan recycling; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function
  
 
 0.714
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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