STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydiPUncharacterized HTH-type transcriptional regulator YdiP; Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent (303 aa)    
Predicted Functional Partners:
yhjB
Putative HTH-type transcriptional regulator YhjB; Putative regulator; Protein involved in transcription activator activity and transcription
  
   
 0.817
ydiN
Putative mfs transporter, membrane protein; Inner membrane transport protein YdiN; Putative amino acid/amine transport protein
 
     0.738
birA
Bira family transcriptional regulator, biotin operon repressor / biotin---[acetyl-coa-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
     
 0.707
dgoR
Gntr family transcriptional regulator, galactonate operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer
     
 0.701
ydiM
Putative mfs transporter, membrane protein; Inner membrane transport protein YdiM; Putative transport system permease protein
 
    0.671
rhaR
Arac family transcriptional regulator, l-rhamnose operon transcriptional activator rhar; Activates expression of the rhaSR operon in response to L- rhamnose
 
   
 0.661
yiaJ
Iclr family transcriptional regulator, carbohydrate utilization repressor; Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate
     
 0.645
citA
Two-component system, citb family, cit operon sensor histidine kinase cita; Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate
  
   
 0.626
fadK
Short chain acyl-coa synthetase, anaerobic; Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6:0, C8:0 and C12:0 fatty acids, while has a low activity on C14-C18 chain length fatty acids Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor . Can fun [...]
 
     0.617
bglJ
Luxr family transcriptional regulator, regulator of transport and utilization of aryl beta-glucosides; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO
  
   
 0.588
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.