node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
baeS | cpxA | b2078 | b3911 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | 0.478 |
baeS | yedV | b2078 | b1968 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR. | 0.460 |
baeS | yedW | b2078 | b1969 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.751 |
basS | cpxA | b4112 | b3911 | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | 0.442 |
basS | yedW | b4112 | b1969 | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.758 |
basS | zraS | b4112 | b4003 | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. | 0.778 |
cpxA | baeS | b3911 | b2078 | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | 0.478 |
cpxA | basS | b3911 | b4112 | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | 0.442 |
cpxA | cusS | b3911 | b0570 | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.409 |
cpxA | phoR | b3911 | b0400 | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | 0.441 |
cpxA | yedW | b3911 | b1969 | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.743 |
cusS | cpxA | b0570 | b3911 | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | 0.409 |
cusS | yedV | b0570 | b1968 | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR. | 0.542 |
cusS | yedW | b0570 | b1969 | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.893 |
cusS | zraS | b0570 | b4003 | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. | 0.404 |
hiuH | yedV | b1970 | b1968 | Hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). | Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR. | 0.609 |
hiuH | yedW | b1970 | b1969 | Hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.776 |
nuoC | yedW | b2286 | b1969 | NADH:ubiquinone oxidoreductase, fused CD subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.672 |
phoR | cpxA | b0400 | b3911 | Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functi [...] | 0.441 |
phoR | yedW | b0400 | b1969 | Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.668 |