node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
amtB | glnK | b0451 | b0450 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | 0.999 |
amtB | nac | b0451 | b1988 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.749 |
cbl | nac | b1987 | b1988 | Lysr family transcriptional regulator, cys regulon transcriptional activator; May be an accessory regulatory protein within the cys regulon | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.747 |
codB | nac | b0336 | b1988 | Cytosine transporter; Required for cytosine transport into the cell | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.430 |
epmC | nac | b2326 | b1988 | Elongation factor p lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.569 |
feaB | feaR | b1385 | b1384 | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde | Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism | 0.949 |
feaB | nac | b1385 | b1988 | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.470 |
feaR | feaB | b1384 | b1385 | Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde | 0.949 |
feaR | nac | b1384 | b1988 | Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.539 |
glnK | amtB | b0450 | b0451 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Ammonium transporter, amt family; Involved in the uptake of ammonia | 0.999 |
glnK | nac | b0450 | b1988 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | 0.741 |
nac | amtB | b1988 | b0451 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Ammonium transporter, amt family; Involved in the uptake of ammonia | 0.749 |
nac | cbl | b1988 | b1987 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Lysr family transcriptional regulator, cys regulon transcriptional activator; May be an accessory regulatory protein within the cys regulon | 0.747 |
nac | codB | b1988 | b0336 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Cytosine transporter; Required for cytosine transport into the cell | 0.430 |
nac | epmC | b1988 | b2326 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Elongation factor p lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine | 0.569 |
nac | feaB | b1988 | b1385 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde | 0.470 |
nac | feaR | b1988 | b1384 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism | 0.539 |
nac | glnK | b1988 | b0450 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | 0.741 |
nac | ycfT | b1988 | b1115 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | annotation not available | 0.450 |
nac | ycgZ | b1988 | b1164 | Lysr family transcriptional regulator, nitrogen assimilation regulatory protein; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) | Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component | 0.482 |