STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wzaOuter membrane polysaccharide export protein wza; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium (379 aa)    
Predicted Functional Partners:
wzc
Colanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg
 
 
 0.999
wzb
Colanic acid production protein-tyrosine-phosphatase; Dephosphorylates Wzc . Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium . Involved in protection of cells against contact- dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact
  
 0.999
etk
Tyrosine-protein kinase, role in o-antigen capsule formation; Belongs to the etk/wzc family
 
 
 0.963
etp
O-antigen capsule forming protein-tyrosine-phosphatase; Dephosphorylates etk
  
 0.960
wzxC
M-antigen undecaprenyl disphosphate flippase; Belongs to the polysaccharide synthase family
 
 
 0.956
wzxB
Polyisoprenol-linked o-antigen repeat unit flippase; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units
   
 
 0.936
wcaA
Putative colanic acid biosynthesis glycosyl transferase WcaA; Putative regulator; Protein involved in colanic acid biosynthetic process
 
  
 0.928
cpsB
Mannose-1-phosphate guanylyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid
  
  
 0.909
wzyE
Putative eca polysaccharide chain elongation protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC))
    
 
 0.907
wzxE
Enterobacterial common antigen flippase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). Could also mediate the translocation of Und-PP-GlcNAc
   
 
 0.902
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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