| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folC | folE | b2315 | b2153 | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 0.958 |
| folC | folK | b2315 | b0142 | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | 0.982 |
| folC | folP | b2315 | b3177 | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.999 |
| folC | queD | b2315 | b2765 | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP | 0.407 |
| folC | ribA | b2315 | b1277 | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | Gtp cyclohydrolase ii; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate | 0.679 |
| folE | folC | b2153 | b2315 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | 0.958 |
| folE | folK | b2153 | b0142 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | 0.987 |
| folE | folP | b2153 | b3177 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.934 |
| folE | folX | b2153 | b2303 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP) . Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli | 0.967 |
| folE | queC | b2153 | b0444 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 7-cyano-7-deazaguanine (preQ0) synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) | 0.944 |
| folE | queD | b2153 | b2765 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP | 0.998 |
| folE | queE | b2153 | b2777 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | Putative 7-carboxy-7-deazaguanine synthase quee; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds | 0.940 |
| folE | queF | b2153 | b2794 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 7-cyano-7-deazaguanine reductase (NADPH-dependent); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway. Is highly specific for its natural substrate preQ0, since it cannot use various aliphatic, aromatic, benzylic and heterocyclic nitriles, such as acetonitrile, benzonitrile, benzylcyanide and 2-cyanopyrrole, although it can reduce the substrate analog 5-cyanopyrrolo[2,3-d]pyrimidin-4-one with lesser efficiency | 0.960 |
| folE | ribA | b2153 | b1277 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | Gtp cyclohydrolase ii; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate | 0.993 |
| folE | yeiB | b2153 | b2152 | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | DUF418 family putative inner membrane protein; Involved in transport | 0.961 |
| folK | folC | b0142 | b2315 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | Bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives | 0.982 |
| folK | folE | b0142 | b2153 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | Gtp cyclohydrolase ia; Belongs to the GTP cyclohydrolase I family | 0.987 |
| folK | folP | b0142 | b3177 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.999 |
| folK | folX | b0142 | b2303 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP) . Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli | 0.668 |
| folK | queD | b0142 | b2765 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Belongs to the HPPK family | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP | 0.543 |
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