STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmFHeme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. (647 aa)    
Predicted Functional Partners:
ccmH
Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
 
 0.999
dsbE
Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD.
  
 0.999
ccmE
Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family.
 
 
 0.999
ccmC
Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 
  
 0.998
ccmB
Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 
  
 0.993
ccmA
Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
 
  
 0.992
ccmD
Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 
  
 0.990
nrfF
Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase.
  
 0.966
nrfG
Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes.
 
  
 0.916
napC
Quinol dehydrogenase, electron source for NapAB; Mediates electron flow from quinones to the NapAB complex.
 
  
 0.788
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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