STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
atoEShort-chain fatty acids transporter; May be responsible for the uptake of short-chain fatty acids (440 aa)    
Predicted Functional Partners:
atoD
Acetate coa/acetoacetate coa-transferase alpha subunit; acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation
  
 0.996
atoA
Acetate coa/acetoacetate coa-transferase beta subunit; Belongs to the 3-oxoacid CoA-transferase subunit B family
  
 0.996
atoB
Acetyl-coa c-acetyltransferase; Acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation
  
  
 0.873
atoC
Dna-binding transcriptional activator/ornithine decarboxylase inhibitor atoc; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine . Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon . AtoC acts by binding directly to the promoter region of the target genes . In [...]
 
  
 0.810
atoS
Sensory histidine kinase in two-component regulatory system with atoc; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine . Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon . AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in respon [...]
 
    0.780
fecD
Ferric citrate abc transporter membrane subunit fecd; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
   
  
 0.658
fadE
Acyl coenzyme a dehydrogenase; Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for E.coli to utilize dodecanoate or oleate as the sole carbon and energy source for growth
   
  
 0.608
fecE
Ferric citrate transport system atp-binding protein; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
      
 0.520
fadR
Gntr family transcriptional regulator, negative regulator for fad regulon and positive regulator of faba; Multifunctional regulator of fatty acid metabolism Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE . Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes
      
 0.422
cpdB
2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate
      
 0.422
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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