node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cvpA | dedD | b2313 | b2314 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | 0.760 |
cvpA | folC | b2313 | b2315 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.655 |
cvpA | ftsN | b2313 | b3933 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable). Required for full FtsI activity. Required for recruitment of AmiC to the septal ring. Belongs to the FtsN family. | 0.428 |
cvpA | ftsQ | b2313 | b0093 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | Divisome assembly protein, membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. Belongs to the FtsQ/DivIB family. FtsQ subfamily. | 0.611 |
cvpA | rlpA | b2313 | b0633 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | Septal ring protein, suppressor of prc, minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family. | 0.428 |
cvpA | zipA | b2313 | b2412 | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | FtsZ stabilizer; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN. ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX. Does not affect the GTPase activity of FtsZ. | 0.463 |
damX | dedD | b3388 | b2314 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | 0.933 |
damX | ftsN | b3388 | b3933 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable). Required for full FtsI activity. Required for recruitment of AmiC to the septal ring. Belongs to the FtsN family. | 0.951 |
damX | ftsQ | b3388 | b0093 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Divisome assembly protein, membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. Belongs to the FtsQ/DivIB family. FtsQ subfamily. | 0.757 |
damX | gmk | b3388 | b3648 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | 0.840 |
damX | rlpA | b3388 | b0633 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Septal ring protein, suppressor of prc, minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family. | 0.904 |
damX | ytfB | b3388 | b4206 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | Cell division protein YtfB; Cell division protein whose function is related to the generation of a transient cell wall structure. Function is linked to the late stages of cell division. | 0.624 |
damX | zipA | b3388 | b2412 | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | FtsZ stabilizer; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN. ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX. Does not affect the GTPase activity of FtsZ. | 0.856 |
dedD | cvpA | b2314 | b2313 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30. | 0.760 |
dedD | damX | b2314 | b3388 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family. | 0.933 |
dedD | folC | b2314 | b2315 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.962 |
dedD | ftsN | b2314 | b3933 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable). Required for full FtsI activity. Required for recruitment of AmiC to the septal ring. Belongs to the FtsN family. | 0.889 |
dedD | ftsQ | b2314 | b0093 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Divisome assembly protein, membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. Belongs to the FtsQ/DivIB family. FtsQ subfamily. | 0.748 |
dedD | gmk | b2314 | b3648 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | 0.811 |
dedD | rlpA | b2314 | b0633 | Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family. | Septal ring protein, suppressor of prc, minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family. | 0.881 |